PuSH - Publikationsserver des Helmholtz Zentrums München: High TCR diversity ensures optimal function and homeostasis of Foxp3<sup>+ </sup>regulatory T cells.

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Fohse, L.* ; Suffner, J.* ; Suhre, K. ; Wahl, B.* ; Lindner, C.* ; Lee, C.W.* ; Schmitz, S.* ; Haas, J.D.* ; Lamprecht, S.* ; Koenecke, C.* ; Bleich, A.* ; Hämmerling, G.J.* ; Malissen, B.* ; Suerbaum, S.* ; Forster, R.* ; Prinz, I.

High TCR diversity ensures optimal function and homeostasis of Foxp3⁺regulatory T cells.

Eur. J. Immunol. 41, 3101-3113 (2011)

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Abstract
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Dominant tolerance to self-antigen requires the presence of sufficient numbers of CD4(+) Foxp3(+) Treg cells with matching antigen specificity. However, the size and role of TCR repertoire diversity for antigen-specific immuno-regulation through Treg cells is not clear. Here, we developed and applied a novel high-throughput (HT) TCR sequencing approach to analyze the TCR repertoire of Treg cells and revealed the importance of high diversity for Treg-cell homeostasis and function. We found that highly polyclonal Treg cells from WT mice vigorously expanded after adoptive transfer into non-lymphopenic TCR-transgenic recipients with low Treg-cell diversity. In that system, we identified specific Treg-cell TCR preferences in distinct anatomic locations such as the mesenteric LN indicating that Treg cells continuously compete for MHC class-II-presented self-, food-, or flora-antigen. Functionally, we showed that high TCR diversity was required for optimal suppressive function of Treg cells in experimental acute graft versus host disease (GvHD). In conclusion, we suggest that efficient immuno-regulation by Treg cells requires high TCR diversity. Thereby, continuous competition of peripheral Treg cells for limited self-antigen shapes an organ-optimized, yet highly diverse, local TCR repertoire.

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0.993

PuSH - Publikationsserver des Helmholtz Zentrums München

High TCR diversity ensures optimal function and homeostasis of Foxp3+ regulatory T cells.

High TCR diversity ensures optimal function and homeostasis of Foxp3⁺regulatory T cells.