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Mitic, N.* ; Neuschulz, A.* ; Spanjaard, B.* ; Schneider, J. ; Fresmann, N.* ; Novoselc, K.T. ; Strunk, T.* ; Münster, L.* ; Olivares-Chauvet, P.* ; Ninkovic, J. ; Junker, J.P.*

Dissecting the spatiotemporal diversity of adult neural stem cells.

Mol. Syst. Biol. 20, 321-337 (2024)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Adult stem cells are important for tissue turnover and regeneration. However, in most adult systems it remains elusive how stem cells assume different functional states and support spatially patterned tissue architecture. Here, we dissected the diversity of neural stem cells in the adult zebrafish brain, an organ that is characterized by pronounced zonation and high regenerative capacity. We combined single-cell transcriptomics of dissected brain regions with massively parallel lineage tracing and in vivo RNA metabolic labeling to analyze the regulation of neural stem cells in space and time. We detected a large diversity of neural stem cells, with some subtypes being restricted to a single brain region, while others were found globally across the brain. Global stem cell states are linked to neurogenic differentiation, with different states being involved in proliferative and non-proliferative differentiation. Our work reveals principles of adult stem cell organization and establishes a resource for the functional manipulation of neural stem cell subtypes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Massively Parallel Lineage Tracing ; Radial Glia ; Single-cell Rna Metabolic Labeling ; Single-cell Transcriptomics ; Zebrafish; Zebrafish Brain; Radial Glia; Neurogenesis; Proliferation; Migration; Origin; Injury; Model
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1744-4292
e-ISSN 1744-4292
Zeitschrift Molecular Systems Biology
Quellenangaben Band: 20, Heft: 4, Seiten: 321-337 Artikelnummer: , Supplement: ,
Verlag EMBO Press
Verlagsort Campus, 4 Crinan St, London, N1 9xw, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
Förderungen Studienstiftung des deutschen Volkes
Helmholtz AI grant
Consolidator Grant
European Research Council Starting Grant
MDC/BIMSB core facilities (zebrafish, genomics, bioinformatics)
DOI 10.1038/s44320-024-00022-z
WOS ID 001220382800001
Scopus ID 85185290647
PubMed ID 38365956
Erfassungsdatum 2024-04-22
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