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Mercado, L.* ; Rose, S.* ; Escalona-Vargas, D.* ; Siegel, E.R.* ; Whittington, J.R.* ; Preissl, H. ; Helmich, M.* ; Eswaran, H.*

Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy.

J. Perinat. Med., DOI: 10.1515/jpm-2023-0413 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
OBJECTIVES: This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique. METHODS: Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood. RESULTS: Brain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (-0.309; -0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood. CONCLUSIONS: In this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Brain-derived Neurotrophic Factor (bdnf) ; Fetal Heart Rate Variability ; Fetal Magnetocardiography ; Inflammatory Markers (il-6); Rate-variability; Factor Bdnf; Cord; Neuroinflammation; Connectivity; Activation; Depression; Birth
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 0300-5577
e-ISSN 1619-3997
Zeitschrift Journal of Perinatal Medicine
Verlag de Gruyter
Verlagsort Genthiner Strasse 13, D-10785 Berlin, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen National Institute of Biomedical Imaging and Bioengineering
DOI 10.1515/jpm-2023-0413
WOS ID 001177269800001
Scopus ID 85186082006
PubMed ID 38404246
Erfassungsdatum 2024-04-24
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