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Demko, V.* ; Belova, T.* ; Messerer, M. ; Hvidsten, T.R.* ; Perroud, P.F.* ; Ako, A.E.* ; Johansen, W.* ; Mayer, K.F.X. ; Olsen, O.A.* ; Lang, D.

Regulation of developmental gatekeeping and cell fate transition by the calpain protease DEK1 in Physcomitrium patens.

Comm. Biol. 7:261 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Calpains are cysteine proteases that control cell fate transitions whose loss of function causes severe, pleiotropic phenotypes in eukaryotes. Although mainly considered as modulatory proteases, human calpain targets are directed to the N-end rule degradation pathway. Several such targets are transcription factors, hinting at a gene-regulatory role. Here, we analyze the gene-regulatory networks of the moss Physcomitrium patens and characterize the regulons that are misregulated in mutants of the calpain DEFECTIVE KERNEL1 (DEK1). Predicted cleavage patterns of the regulatory hierarchies in five DEK1-controlled subnetworks are consistent with a pleiotropic and regulatory role during cell fate transitions targeting multiple functions. Network structure suggests DEK1-gated sequential transitions between cell fates in 2D-to-3D development. Our method combines comprehensive phenotyping, transcriptomics and data science to dissect phenotypic traits, and our model explains the protease function as a switch gatekeeping cell fate transitions potentially also beyond plant development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Defective Kernel 1; 3d Growth Transition; Transcription Factors; Arabidopsis; Model; Maize; Phosphoproteomics; Specification; Initiation; Prediction
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Zeitschrift Communications Biology
Quellenangaben Band: 7, Heft: 1, Seiten: , Artikelnummer: 261 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Plant Genome and Systems Biology (PGSB)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-503500-002
Förderungen Slovak Research and Development Agency
FRIMEDBIO grant from the Norwegian Research Council
Southeastern Regional Health Authorities
Functional Genomics and Infrastructure programs of the Research Council of Norway
Norwegian Research Council
FRIMEDBIO
Norges Forskningsrd (Research Council of Norway)
DOI 10.1038/s42003-024-05933-z
WOS ID 001179826800008
Scopus ID 85186605858
PubMed ID 38438476
Erfassungsdatum 2024-04-26
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