PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Babushku, T. ; Lechner, M. ; Ehrenberg, S. ; Rambold, U. ; Schmidt-Supprian, M.* ; Yates, A.J.* ; Rane, S.* ; Zimber-Strobl, U. ; Strobl, L.J.

Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization.

Nat. Commun. 15:1960 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still elusive. Here, we demonstrate that most B cells receive a basal Notch signal, which is intensified in pre-MZB and MZB cells. Ablation or constitutive activation of Notch2 upon T-cell-dependent immunization reveals an interplay between antigen-induced activation and Notch2 signaling, in which FoB cells that turn off Notch2 signaling enter germinal centers (GC), while high Notch2 signaling leads to generation of MZB cells or to initiation of plasmablast differentiation. Notch2 signaling is dispensable for GC dynamics but appears to be re-induced in some centrocytes to govern expansion of IgG1+ GCB cells. Mathematical modelling suggests that antigen-activated FoB cells make a Notch2 dependent binary fate-decision to differentiate into either GCB or MZB cells. This bifurcation might serve as a mechanism to archive antigen-specific clones into functionally and spatially diverse B cell states to generate robust antibody and memory responses.
Impact Factor
Scopus SNIP
Altmetric
14.700
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Positive Selection; Gene-expression; Distinct; Blimp-1; Differentiation; Visualization; Delta-like-1; Activation; Ligands; Bcl6
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 1960 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)
Institute of Asthma and Allergy Prevention (IAP)
Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30203 - Molecular Targets and Therapies
30202 - Environmental Health
Forschungsfeld(er) Immune Response and Infection
Allergy
Lung Research
PSP-Element(e) G-501500-003
G-503300-001
G-505000-007
Förderungen Deutsche Forschungsgemeinschaft (German Research Foundation)
National Institute of Allergy and Infectious Diseases of the National Institutes of Health
DOI 10.1038/s41467-024-46024-1
WOS ID 001179853600005
Scopus ID 85186551104
PubMed ID 38438375
Erfassungsdatum 2024-04-26
[➜Korrektur melden]