PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Hakola, L.* ; Mramba, L.K.* ; Uusitalo, U.* ; Andrén Aronsson, C.* ; Hummel, S. ; Niinistö, S.* ; Erlund, I.* ; Yang, J.* ; Rewers, M.J.* ; Akolkar, B.* ; McIndoe, R.A.* ; Rich, S.S.* ; Hagopian, W.A.* ; Ziegler, A.-G. ; Lernmark, Å.* ; Toppari, J.* ; Krischer, J.P.* ; Norris, J.M.* ; Virtanen, S.M.* ; TEDDY Study Group (Gezginci, C. ; Heublein, A. ; Knopff, A. ; Koletzko, S. ; Ramminger, C. ; Roth, R. ; Schmidt, J. ; Scholz, M. ; Stock, J. ; Warncke, K. ; Wendel, L. ; Winkler, C.)

Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study.

Eur. J. Nutr., DOI: 10.1007/s00394-024-03346-6 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D.  CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
Impact Factor
Scopus SNIP
Altmetric
4.100
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Birth Cohort ; Diabetes Mellitus, Type 1 ; Nutrient Intake ; Vitamin B Complex; Autoantibodies; Energy
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1436-6207
e-ISSN 1436-6215
Zeitschrift European Journal of Nutrition
Verlag Springer
Verlagsort Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
G-501900-021
Förderungen National Institute of Diabetes and Digestive and Kidney Diseases
DOI 10.1007/s00394-024-03346-6
WOS ID 001180435400001
Scopus ID 85186206593
PubMed ID 38413484
Erfassungsdatum 2024-04-30
[➜Korrektur melden]