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Telpoukhovskaia, M.A.* ; Murdy, T.J.* ; Marola, O.J.* ; Charland, K.* ; MacLean, M.* ; Luquez, T.* ; Lish, A.M.* ; Neuner, S.* ; Dunn, A.* ; Onos, K.D.* ; Wiley, J.* ; Archer, D.* ; Huentelman, M.J.* ; Arnold, M. ; Menon, V.* ; Goate, A.* ; Van Eldik, L.J.* ; Territo, P.R.* ; Howell, G.R.* ; Carter, G.W.* ; O'Connell, K.M.S.* ; Kaczorowski, C.C.*

New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.

Alzheimers Dement. 10:e12458 (2024)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
INTRODUCTION: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic. RESULTS: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management. DISCUSSION: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Alzheimers-disease; Connectivity Map; Resilience; Pathways
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1552-5260
e-ISSN 1552-5279
Zeitschrift Alzheimer's & Dementia
Quellenangaben Band: 10, Heft: 1, Seiten: , Artikelnummer: e12458 Supplement: ,
Verlag Elsevier
Verlagsort New York, NY [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503891-001
Förderungen National Institute of Health/National Institute on Aging
National Institute on Aging
National Institutes of Health
National Institute of Aging
Alzheimer's Association Zenith Fellows Award
JAX Center for Alzheimer's and Dementia Research (CADR)

Alzheimer's Association
DOI 10.1002/trc2.12458
WOS ID 001181630700001
WOS ID 001191400700002
Scopus ID 85187174689
PubMed ID 38469553
Erfassungsdatum 2024-05-08
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