PuSH - Publikationsserver des Helmholtz Zentrums München: Detecting metastatic patterns of oligometastatic breast cancer: A comparative analysis of <sup>18</sup>F-FDG PET/CT and conventional CT imaging.

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Moser, R.* ; Pfeiffer, S.* ; Cala, L.* ; Klein, E.* ; Kiechle, M.* ; Behzadi, S.T.* ; Fallenberg, E.M.* ; Combs, S.E. ; Weber, W.* ; Borm, K.J.*

Detecting metastatic patterns of oligometastatic breast cancer: A comparative analysis of ¹⁸F-FDG PET/CT and conventional CT imaging.

J. Nucl. Med. 65, 845-850 (2024)

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Metastasis-directed therapy has the potential to improve progression-free and overall survival in oligometastatic disease (OMD). For breast cancer, however, randomized trials have failed so far to confirm this finding. Because the concept of metastasis-directed therapy in OMD is highly dependent on the accuracy of the imaging modality, we aimed to assess the impact of ¹⁸F-FDG PET/CT on the definition of OMD in breast cancer patients. Methods: Eighty patients with a total of 150 ¹⁸F-FDG PET/CT images (between October 2006 and January 2022) were enrolled in this retrospective study at the Technical University of Munich. The inclusion criteria were OMD, defined as 1-5 distant metastases, at the time of ¹⁸F-FDG PET/CT. For the current study, we systemically compared the metastatic pattern on ¹⁸F-FDG PET/CT with conventional CT. Results: At the time of ¹⁸F-FDG PET/CT, 21.3% of patients (n = 32) had a first-time diagnosis of metastatic disease, 40.7% (n = 61) had a previous history of OMD, and 38% (n = 57) had a previous history of polymetastatic disease. In 45.3% of cases, the imaging modality (¹⁸F-FDG PET/CT vs. conventional CT) had an impact on the assessment of whether OMD was present. An identical metastatic pattern was observed in only 32% of cases.¹⁸F-FDG PET/CT detected additional metastases in 33.3% of cases, mostly in the nonregional lymph node system. Conclusion: The use of ¹⁸F-FDG PET/CT had a substantial impact on the definition of OMD and detection of metastatic pattern in breast cancer. Our results emphasize the importance of establishing a standardized definition for imaging modalities in future trials and clinical practices related to metastasis-directed therapy in breast cancer patients.

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PuSH - Publikationsserver des Helmholtz Zentrums München

Detecting metastatic patterns of oligometastatic breast cancer: A comparative analysis of 18F-FDG PET/CT and conventional CT imaging.

Detecting metastatic patterns of oligometastatic breast cancer: A comparative analysis of ¹⁸F-FDG PET/CT and conventional CT imaging.