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Hopff, S.M.* ; Appel, K.S.* ; Miljukov, O.* ; Schneider, J.* ; Addo, M.M.* ; Bals, R.* ; Bercker, S.* ; Blaschke, S.* ; Bröhl, I.* ; Büchner, N.* ; Dashti, H.S.* ; Erber, J.* ; Friedrichs, A.* ; Geisler, R.* ; Göpel, S.* ; Hagen, M.* ; Hanses, F.* ; Jensen, B.O.* ; Keul, M.* ; Krawczyk, A.* ; Lorenz-Depiereux, B. ; Meybohm, P.* ; Milovanovic, M.* ; Mitrov, L.* ; Nürnberger, C.* ; Obst, W.* ; Römmele, C.* ; Schäfer, C.* ; Scheer, C.E.* ; Scherer, M.* ; Schmidt, J.* ; Seibel, K.* ; Sikdar, S.* ; Tebbe, J.J.* ; Tepasse, P.R.* ; Thelen, P.* ; Vehreschild, M.J.G.T.* ; Weismantel, C.* ; Vehreschild, J.J.*

Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP).

Infection, DOI: 10.1007/s15010-024-02270-5 (2024)

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PURPOSE: The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron. METHODS: We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points. RESULTS: We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95% CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron. CONCLUSION: With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU. CLINICAL TRAIL REGISTRATION: The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998).

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