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Keipert, S.* ; Gaudry, M.J.* ; Kutschke, M.* ; Keuper, M.* ; Dela Rosa, M.A.S.* ; Cheng, Y. ; Monroy Kuhn, J.M. ; Laterveer, R.* ; Cotrim, C.A.* ; Giere, P.* ; Perocchi, F. ; Feederle, R. ; Crichton, P.G.* ; Lutter, D. ; Jastroch, M.*

Two-stage evolution of mammalian adipose tissue thermogenesis.

Science 384, 1111-1117 (2024)
Postprint DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Brown adipose tissue (BAT) is a heater organ that expresses thermogenic uncoupling protein 1 (UCP1) to maintain high body temperatures during cold stress. BAT thermogenesis is considered an overarching mammalian trait, but its evolutionary origin is unknown. We show that adipose tissue of marsupials, which diverged from eutherian mammals ~150 million years ago, expresses a nonthermogenic UCP1 variant governed by a partial transcriptomic BAT signature similar to that found in eutherian beige adipose tissue. We found that the reconstructed UCP1 sequence of the common eutherian ancestor displayed typical thermogenic activity, whereas therian ancestor UCP1 is nonthermogenic. Thus, mammalian adipose tissue thermogenesis may have evolved in two distinct stages, with a prethermogenic stage in the common therian ancestor linking UCP1 expression to adipose tissue and thermal stress. We propose that in a second stage, UCP1 acquired its thermogenic function specifically in eutherians, such that the onset of mammalian BAT thermogenesis occurred only after the divergence from marsupials.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Uncoupling Protein-1; Identification; Nucleotides; Slc25; Ucp1; Fat
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 384, Heft: 6700, Seiten: 1111-1117 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort 1200 New York Ave, Nw, Washington, Dc 20005 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
CF Monoclonal Antibodies (CF-MAB)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
G-502297-001
G-502295-001
A-631900-001
Förderungen Wenner-Gren Foundation
Vetenskapsradet
Novo Nordisk Fonden
DOI 10.1126/science.adg1947
WOS ID 001253276700028
Scopus ID 85195438772
PubMed ID 38843333
Erfassungsdatum 2024-07-08
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