PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Weinisch, P. ; Raffler, J. ; Römisch-Margl, W. ; Arnold, M. ; Mohney, R.P.* ; Rist, M.J.* ; Prehn, C. ; Skurk, T.* ; Hauner, H.* ; Daniel, H.* ; Suhre, K.* ; Kastenmüller, G.

The HuMet Repository: Watching human metabolism at work.

Cell Rep. 43:114416 (2024)
Postprint DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, exercise, and cold stress in healthy subjects. Metabolomics data from blood, urine, and breath of 15 young, healthy men at up to 56 time points are integrated and embedded within an interactive web application, enabling researchers with and without computational expertise to search, visualize, analyze, and contextualize the dynamic metabolite profiles of 2,656 metabolites acquired on multiple platforms. With examples, we demonstrate the utility of the resource for research into the dynamics of human metabolism, highlighting differences and similarities in systemic metabolic responses across challenges and the complementarity of metabolomics platforms. The repository, providing a reference for healthy metabolite changes to six standardized physiological challenges, is freely accessible through a web portal.
Impact Factor
Scopus SNIP
Altmetric
7.500
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cp: Metabolism ; Dynamic Metabolic Responses In Health ; Exercise Metabolism ; Metabolic Flexibility ; Metabolomics Platform Comparison ; Oral Glucose Tolerance Test ; Oral Lipid Tolerance Test ; Postprandial Metabolism ; Prolonged/extended Fasting ; Standardized Physiological Challenge Tests ; Time-series Metabolomics; Human Blood; Metabolomics; Associations; Imputation; Pathways; Markers
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 43, Heft: 8, Seiten: , Artikelnummer: 114416 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
CF Metabolomics & Proteomics (CF-MPC)
POF Topic(s) 30205 - Bioengineering and Digital Health
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503891-001
A-630710-001
Förderungen De.NBI Cloud within the German Network for Bio-informatics Infrastructure (de.NBI) - German Federal Ministry of Education and Research (BMBF)
National Institutes of Health/National Institute on Aging
Qatar Foundation
Biomedical Research Program at Weill Cornell Medicine in Qatar
German Federal Ministry of Education and Research (BMBF)
Else Kroner-Fresenius Foundation, Bad Homburg, Germany
DOI 10.1016/j.celrep.2024.114416
WOS ID 001276325900001
Scopus ID 85199059032
PubMed ID 39033506
Erfassungsdatum 2024-07-22
[➜Korrektur melden]