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Kreitmaier, P. ; Swift, D.* ; Wilkinson, J.M.* ; Zeggini, E.

Epigenomic differences between osteoarthritis grades in primary cartilage.

Osteoarthr. Cartil. 32, 1126-1133 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
OBJECTIVE: Osteoarthritis is a common and complex joint disorder that shows higher prevalence and greater disease severity in women. Here, we investigate genome-wide methylation profiles of primary chondrocytes from osteoarthritis patients. DESIGN: We compare genome-wide methylation profiles of macroscopically intact (low-grade) and degraded (high-grade) osteoarthritis cartilage samples matched from osteoarthritis patients undergoing knee replacement surgery. We perform an epigenome-wide association study (EWAS) for cartilage degeneration across 170 patients and separately in 96 women and 74 men. RESULTS: We reveal widespread epigenetic differences with enrichments of nervous system and apoptosis-related processes. We further identify substantial similarities between sexes, but also sex-specific markers and pathways. CONCLUSIONS: Together, we provide the largest genome-wide methylation profiles of primary cartilage to date with enhanced and sex-specific insights into epigenetic processes underlying osteoarthritis progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dna Methylation ; Ewas ; Osteoarthritis ; Cartilage ; Chondrocytes ; Sex Specificity; Sex-differences; Knee; Identification; Associations; Disability; Package; Pain
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1063-4584
e-ISSN 1063-4584
Zeitschrift Osteoarthritis and Cartilage
Quellenangaben Band: 32, Heft: 9, Seiten: 1126-1133 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 125 London Wall, London, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-506700-001
DOI 10.1016/j.joca.2024.07.008
WOS ID 001298018000001
Scopus ID 85200366656
PubMed ID 39053729
Erfassungsdatum 2024-07-29
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