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Sommer-Ballarini, M.* ; Nguyen, T.H.* ; Pletsch-Borba, L.* ; Wernicke, C.* ; Tacke, F.* ; Schwerdtle, T.* ; Pellowski, D.* ; Machann, J. ; Spranger, J.* ; Wirth, E.K.* ; Mai, K.*

Impact of peripheral thyroid hormone balance on liver fat: Insights from the NutriAct trial.

Eur. J. Endocrinol. 191, 183-191 (2024)
Postprint DOI PMC
Open Access Green
OBJECTIVE: Hypothyroidism has been proposed as a potential contributor to steatotic liver disease (SLD), but existing data shows conflicting results in euthyroid subjects. Therefore, we investigated the association between thyroid function and intrahepatic lipids (IHLs) during a 36-months randomized controlled trial evaluating a diet known to reduce liver fat. DESIGN: 502 eligible subjects (aged 50 to 80 y, ≥ 1 risk factor for unhealthy aging) were randomly assigned to either follow a diet rich in unsaturated fatty acids, plant protein and fiber (intervention group, IG), or dietary recommendations of the German Nutrition Society (control group (CG)). METHODS: Serum levels of thyroid hormones (THs) as well as IHLs, defined via magnetic resonance spectroscopy, were measured within an euthyroid subgroup without significant alcohol consumption at baseline (n = 332) and after 12 months (n = 243). Ratio of T3/T4 was used to assess whole body deiodinase activity. Estimates of glucose and lipid metabolism were analyzed. RESULTS: Only fT3 and T3/T4 ratio showed a significant positive correlation with IHL at baseline. We observed a significant decline in fT3, T3, fT3/fT4 ratio and T3/T4 ratio in CG and IG after 12 months without significant differences between groups. TSH, fT4 and T4 remained stable. A larger improvement of IHL during dietary intervention was seen in those subjects with a lower decline in T3 concentrations. CONCLUSIONS: Altered TH balance indicates a possible compensatory upregulation of whole body TH activity in subjects with increased liver fat. This might be also relevant during improvement of hepatic steatosis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Masld ; Nafld ; Diet ; Intrahepatic Lipids ; Steatosis ; Thyroid Hormones; Magnetic-resonance-spectroscopy; Free-thyroxine; Weight-loss; Disease; Hypothyroidism; Deiodinase; Parameters; Nafld; Triiodothyronine; Type-1
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 0804-4643
e-ISSN 1479-683X
Zeitschrift European Journal of Endocrinology
Quellenangaben Band: 191, Heft: 2, Seiten: 183-191 Artikelnummer: , Supplement: ,
Verlag BioScientifica
Verlagsort Great Clarendon St, Oxford Ox2 6dp, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen Bundesministerium fur Forschung und Bildung (BMBF)
Bundesministerium fur Forschung und Bildung (BMBF, German Federal Ministry)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
DOI 10.1093/ejendo/lvae093
WOS ID 001290083300001
Scopus ID 85201308558
PubMed ID 39049801
Erfassungsdatum 2024-07-29
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