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Trigg, N.* ; Schjenken, J.E.* ; Martin, J.H.* ; Skerrett-Byrne, D.A. ; Smyth, S.P.* ; Bernstein, I.R.* ; Anderson, A.L.* ; Stanger, S.J.* ; Simpson, E.N.A.* ; Tomar, A. ; Teperino, R. ; Conine, C.C.* ; De Iuliis, G.N.* ; Roman, S.D.* ; Bromfield, E.G.* ; Dun, M.D.* ; Eamens, A.L.* ; Nixon, B.*

Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice.

Proc. Natl. Acad. Sci. U.S.A. 121:e2409790121 (2024)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Forecasted increases in the prevalence and severity of extreme weather events accompanying changes in climatic behavior pose potential risk to the reproductive capacity of humans and animals of ecological and agricultural significance. While several studies have revealed that heat stress induced by challenges such as testicular insulation can elicit a marked negative effect on the male reproductive system, and particularly the production of spermatozoa, less is known about the immediate impact on male reproductive function following subchronic whole-body exposure to elevated ambient temperature. To address this knowledge gap, we exposed unrestrained male mice to heat stress conditions that emulate a heat wave (daily cycle of 8 h at 35 °C followed by 16 h at 25 °C) for a period of 7 d. Neither the testes or epididymides of heat-exposed male mice exhibited evidence of gross histological change, and similarly, spermatozoa of exposed males retained their functionality and ability to support embryonic development. However, the embryos generated from heat-exposed spermatozoa experienced pronounced changes in gene expression linked to acceleration of early embryo development, aberrant blastocyst hatching, and increased fetal:placental weight ratio. Such changes were causally associated with an altered sperm small noncoding RNA (sncRNA) profile, such that these developmental phenotypes were recapitulated by microinjection of wild-type embryos sired by control spermatozoa with RNAs extracted from heat-exposed spermatozoa. Such data highlight that even relatively modest excursions in ambient temperature can affect male reproductive function and identify the sperm sncRNA profile as a particular point of vulnerability to this imposed environmental stress.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Embryo Development ; Epididymis ; Heat ; Small Non-protein-coding Rna ; Sperm; Seminal Plasma Proteome; Scrotal Heat-stress; Fertilization; Spermatozoa; Quality; Cattle; Mechanisms; Insulation; Responses; Testes
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 121, Heft: 47, Seiten: , Artikelnummer: e2409790121 Supplement: ,
Verlag National Academy of Sciences
Verlagsort 2101 Constitution Ave Nw, Washington, Dc 20418 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500693-001
Förderungen Defeat Diffuse Intrinsic Pontine Glimoa ChadTough New Investigator Fellowship
NHMRC
National Health and Medical Research Council of Australia (NHMRC)
DOI 10.1073/pnas.2409790121
WOS ID 001369429400007
Scopus ID 85209473496
PubMed ID 39527742
Erfassungsdatum 2024-11-15
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