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Mu, L. ; Berti, L. ; Masserdotti, G. ; Covic, M. ; Michaelidis, T.M. ; Doberauer, K. ; Merz, K. ; Rehfeld, F. ; Haslinger, A. ; Wegner, M.* ; Sock, E.* ; Lefebvre, V.* ; Couillard-Despres, S.* ; Aigner, L.* ; Berninger, B. ; Lie, D.C.

SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.

J. Neurosci. 32, 3067-3080 (2012)
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Neural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult NSCs, whereas ablation of Sox4/Sox11 prevents in vitro and in vivo neurogenesis from adult NSCs. Moreover, we demonstrate that SoxC transcription factors target the promoters of genes that are induced on neuronal differentiation of adult NSCs. Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of SoxC factors. These data identify SoxC proteins as essential contributors to the genetic network controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter NEURAL STEM-CELLS; NEWLY GENERATED NEURONS; CENTRAL-NERVOUS-SYSTEM; STAGE-SPECIFIC ROLE; IN-VIVO; POSTNATAL ASTROGLIA; ANALYSIS REVEALS; DNA-BINDING; EXPRESSION; GENE
Sprache
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Zeitschrift Journal of Neuroscience
Quellenangaben Band: 32, Heft: 9, Seiten: 3067-3080 Artikelnummer: , Supplement: ,
Verlag Society for Neuroscience
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Stem Cell Research (ISF)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
Stem Cell and Neuroscience
PSP-Element(e) G-500590-001
G-500500-001
G-500800-001
PubMed ID 22378879
DOI 10.1523/JNEUROSCI.4679-11.2012
WOS ID WOS:000300938100014
Scopus ID 84857551993
Erfassungsdatum 2012-03-28
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