PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Allara, E.* ; Bell, S.* ; Smith, R.* ; Keene, S.J.* ; Gill, D.* ; Gaziano, L.* ; Morselli Gysi, D.* ; Wang, F.* ; Tragante, V.* ; Mason, A.* ; Karthikeyan, S.* ; Lumbers, R.T.* ; Bonglack, E.* ; Ouwehand, W.* ; Roberts, D.J.* ; Dowsett, J.* ; Ostrowski, S.R.* ; Larsen, M.H.* ; Ullum, H.* ; Pedersen, O.B.* ; Brunak, S.* ; Banasik, K.* ; Erikstrup, C.* ; Mitchell, J.* ; Fuchsberger, C.* ; Pattaro, C.* ; Pramstaller, P.P.* ; Girelli, D.* ; Arvas, M.* ; Toivonen, J.* ; Molnos, S. ; Peters, A. ; Polasek, O.* ; Rudan, I.* ; Hayward, C.* ; McDonnell, C.* ; Pirastu, N.* ; Wilson, J.F.* ; van den Hurk, K.* ; Quee, F.* ; Ferrucci, L.* ; Bandinelli, S.* ; Tanaka, T.* ; Girotto, G.* ; Concas, M.P.* ; Pecori, A.* ; Verweij, N.* ; van der Harst, P.* ; van de Vegte, Y.J.* ; Kiemeney, L.A.* ; Sweep, F.C.* ; Galesloot, T.E.* ; Sulem, P.* ; Gudbjartsson, D.* ; Ferkingstad, E.* ; Djousse, L.* ; Cho, K.* ; Inouye, M.* ; Burgess, S.* ; Benyamin, B.* ; Oexle, K. ; Swinkels, D.W.* ; Stefansson, K.* ; Magnusson, M.* ; Ganna, A.* ; Gaziano, M.* ; Ivey, K.* ; Danesh, J.* ; Pereira, A.* ; Wood, A.M.* ; Butterworth, A.S.* ; di Angelantonio, E.*

Novel loci and biomedical consequences of iron homoeostasis variation.

Comm. Biol. 7:1631 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported. Mapping to putative genes indicated involvement in iron-trait expression, erythropoiesis, immune response and cellular trafficking. Mendelian randomisation of 292 disease outcomes in 1,492,717 participants revealed associations of iron-related loci and iron status with selected health outcomes across multiple domains. These associations were largely driven by HFE, which was associated with the largest iron variation. Our findings enhance understanding of iron homoeostasis and its biomedical consequences, suggesting that lifelong exposure to higher iron levels is likely associated with lower risk of anaemia-related disorders and higher risk of genitourinary, musculoskeletal, infectious and neoplastic diseases.
Impact Factor
Scopus SNIP
Altmetric
5.200
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Coronary-heart-disease; Ferric Carboxymaltose; Risk; Deficiency; Failure; Metaanalysis; Association; Biobank; Stores; Mice
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Zeitschrift Communications Biology
Quellenangaben Band: 7, Heft: 1, Seiten: , Artikelnummer: 1631 Supplement: ,
Verlag Springer
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Neurogenomics (ING)
POF Topic(s) 30202 - Environmental Health
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-002
G-504000-010
G-503200-001
Förderungen British Heart Foundation
Department of Innovation, Research
University of the Autonomous Province of Bolzano-South Tyrol
EuropeanRegionalDevelopment Fund
LURM Research Facility at the University Hospital of Verona
Medical Research Council (UK)
European Commission
Republic ofCroatia Ministry of Science, Education, and Sports
anMRC Human Genetics Unit programme grant, 'Quantitative traits in health and disease'
Danish Council for IndependentResearch
Bio-andGenome BankDenmark
The Danish Council for IndependentResearch
Novo Nordisk Foundation
Finnish Funding Agency for Technology and Innovation (Tekes)
VTR funding from the Finnish Government
Business Finland
Innovative Medicines Initiative-2 Joint Undertaking
NIHR
National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre
UK Medical Research Council
Engineering and Physical Sciences Research Council
Economic and Social Research Council
Department of Health and Social Care (England)
Chief Scientist Office of the Scottish Government Health and Social Care Directorates
Health and Social Care Research and Development Division (Welsh Government)
Public Health Agency (Northern Ireland)
Wellcome
Cancer Research UK
NIHR Blood and Transplant Research Unit (BTRU) in Donor Health and Behaviour
Rhodes Trust
Wellcome Trust
United KingdomResearch and InnovationMedical Research Council
National Institute for Health Research Cambridge Biomedical Research Centre
AbbVie Inc.
The Italian Ministry of Health
NIHR Blood and Transplant Research Unit in Donor Health and Genomics
BritishHeart Foundation
NIHRCambridgeBRC
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
Dutch Kidney Foundation
EU
National Institutes of Health
Netherlands organisation for health research and development (NWO-Groot grant )
Dutch Inter University Cardiology Institute Netherlands (ICIN)
Telethon, Italy
Ministry ofHealth
AstraZeneca UK Ltd
Biogen MA Inc.
Bristol Myers Squibb
Genentech Inc.
Merck Sharp Dohme LCC
Pfizer Inc.
GlaxoSmithKline Intellectual Property Development Ltd.
Sanofi US Services Inc.
Maze Therapeutics Inc
Janssen Biotech Inc
Novartis AG
Boehringer Ingelheim International GmbH
Italian Ministry of Health
U.S. National Institute on Aging
Compagnia di San Paolo, Torino, Italy
Fondazione Cariplo, Italy
NWO VENI grant
DOI 10.1038/s42003-024-07115-3
WOS ID 001385774900001
Scopus ID 85211476953
PubMed ID 39643614
Erfassungsdatum 2024-12-10
[➜Korrektur melden]