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Pantazopoulos, D.* ; Gouveri, E.* ; Ntziachristos, V. ; Papanas, N.*

Raster Scan optoacoustic Mesoscopy for detecting microvascular complications in diabetes mellitus: A narrative brief review.

Diabetes Res. Clin. Pract. 222:112095 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Diabetes mellitus (DM) may lead to microvascular and macrovascular complications. Screening for these complications is crucial and non-invasive methods with high-dissemination potential are needed. Diabetic peripheral neuropathy (DPN) is particularly challenging to screen due to the lack of reliable clinical markers and endpoints. In this context, Raster Scan Optoacoustic Mesoscopy (RSOM) emerges as a highly promising technique that offers hybrid, non-invasive imaging of optical absorption using light-induced ultrasound waves within tissue without the use of contrast agents. RSOM provides high-resolution visualisation of micro-vasculature, other tissue structures and functional information. The technique has already assessed microvasculature loss as a function of diabetes progression and used it to characterise DPN severity. RSOM has also shown that cutaneous vessels in the mesoscopic range (mean diameters of 30-40 µm) are most prominently affected by DM and that the mean number of cutaneous vessels was lower in subjects with DM than in healthy participants (p < 0.001 and p < 0.05, respectively). Although experience is still limited, we present an overview of the novel technique in relation to its potential for detecting early DM onset and development of mircovascular complications.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Diabetes ; Diabetic Peripheral Neuropathy ; Microvascular Complications ; Microvasculature ; Optoacoustic Imaging ; Raster Scan Optoacoustic Mesoscopy; Tomography; Neuropathy; Dysfunction; Ultrasound; Microscopy; Microcirculation; Oxygenation; Metabolism; Frequency
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0168-8227
e-ISSN 1872-8227
Zeitschrift Diabetes Research and Clinical Practice
Quellenangaben Band: 222, Heft: , Seiten: , Artikelnummer: 112095 Supplement: ,
Verlag Elsevier
Verlagsort Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
Förderungen European Union
DOI 10.1016/j.diabres.2025.112095
WOS ID 001449823300001
Scopus ID 86000617205
PubMed ID 40073947
Erfassungsdatum 2025-05-07
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