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Campbell, S.J.* ; Utinger, B.* ; Barth, A.* ; Leni, Z.* ; Zhang, Z.H.* ; Resch, J.* ; Li, K.* ; Steimer, S.S.* ; Banach, C.* ; Gfeller, B.* ; Wragg, F.P.H.* ; Westwood, J.* ; Wolfer, K.* ; Bukowiecki, N.* ; Ihalainen, M.* ; Yli-Pirilä, P.* ; Somero, M.* ; Kortelainen, M.* ; Louhisalmi, J.* ; Sklorz, M. ; Czech, H. ; Di Bucchianico, S. ; Streibel, T. ; Delaval, M.N. ; Rüger, C.* ; Baumlin, N.* ; Salathe, M.* ; Fang, Z.* ; Pardo, M.* ; D'Aronco, S.* ; Giorio, C.* ; Shi, Z.* ; Harrison, R.M.* ; Green, D.C.* ; Kelly, F.J.* ; Rudich, Y.* ; Paulson, S.E.* ; Sippula, O.* ; Zimmermann, R. ; Geiser, M.* ; Kalberer, M.*

Short-lived reactive components substantially contribute to particulate matter oxidative potential.

Sci. Adv. 11:eadp8100 (2025)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Exposure to airborne particulate matter (PM) has been attributed to millions of deaths annually. However, the PM components responsible for observed health effects remain unclear. Oxidative potential (OP) has gained increasing attention as a key property that may explain PM toxicity. Using online measurement methods that impinge particles for OP quantification within seconds, we reveal that 60 to 99% of reactive oxygen species (ROS) and OP in secondary organic aerosol and combustion-generated PM have a lifetime of minutes to hours and that the ROS activity of ambient PM decays substantially before offline analysis. This implies that current offline measurement methods substantially underestimate the true OP of PM. We demonstrate that short-lived OP components activate different toxicity pathways upon direct deposition onto reconstituted human bronchial epithelia. Therefore, we suggest that future air pollution and health studies should include online OP quantification, allowing more accurate assessments of links between OP and health effects.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Secondary Organic Aerosol; Oxygen Species Ros; Extended Follow-up; Air-pollution; Respiratory Health; Online Instrument; Direct Deposition; Particles; Exposure; Toxicity
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Zeitschrift Science Advances
Quellenangaben Band: 11, Heft: 12, Seiten: , Artikelnummer: eadp8100 Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington, DC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Cooperation Group Comprehensive Molecular Analytics (CMA)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Environmental Sciences
PSP-Element(e) G-504500-001
Förderungen Helmholtz International Laboratory aero HEALTH
EPSRC UKRI Postdoc guarantee funding grant
European Research Council (ERC)
Natural Environment Research Council (NERC)
Eurochamp
PhotOchemIStry, oxidative pOteNtial and tOxicity of Urban aeroSol (POISONOUS)
Supporting TAlent in ReSearch@University of Padova (STARS-StG MOCAA)
Horizon Europe Framework Program (EASVOLEE)
AXA Research Fund through a 2017- LIFE- PostDoc fellowship
Horizon 2020 project ULTRHAS
SNF
DOI 10.1126/sciadv.adp8100
WOS ID 001447531300002
Scopus ID 105000905392
PubMed ID 40106561
Erfassungsdatum 2025-05-09
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