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Frankenberger, M. ; Ekici, A.B.* ; Angstwurm, M.W.* ; Hoffmann, H.* ; Hofer, T.P. ; Heimbeck, I. ; Meyer, P. ; Lohse, P.* ; Wjst, M. ; Häussinger, K.* ; Reis, A.* ; Ziegler-Heitbrock, L.

A defect of CD16-positive monocytes can occur without disease.

Immunobiology 218, 169-174 (2013)
Verlagsversion Volltext DOI PMC
Open Access Gold
The CD16-positive monocytes have been first described in 1988 but to date no selective defect in the number of these cells in blood has been reported. We now describe a family in which three of four siblings lack both CD16-positive monocyte subsets, i.e. the nonclassical and the intermediate monocytes. All three had CD16-positive monocytes of 2cells/μl or less as compared to 52±18cells/μl in healthy controls. The index case was affected by recurrent pleural effusion and infections and had evidence of an auto-inflammatory condition but no mutation of any of the relevant candidate genes. The other two siblings without CD16-positive monocytes were apparently healthy. There was no defect in serum M-CSF levels and no mutation in the M-CSF and M-CSFR genes. The data indicate that the absence of CD16-positive monocytes in blood does not lead to disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Monocyte subsets; CD16-positive monocytes; Human peripheral blood; Colony-stimulating Factor ; Human Peripheral-blood ; Cd14(+)cd16(+) Monocytes ; Sporadic Monocytopenia ; Autosomal-dominant ; Cd16(+) Monocytes ; Linkage Analysis ; Macrophage ; Expression ; Identification
Sprache englisch
Veröffentlichungsjahr 2013
Prepublished im Jahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0171-2985
e-ISSN 1878-3279
Zeitschrift Immunobiology : Experimental and Clinical
Quellenangaben Band: 218, Heft: 2, Seiten: 169-174 Artikelnummer: , Supplement: ,
Verlag Urban & Fischer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-012
G-505000-003
G-501690-001
PubMed ID 22459269
DOI 10.1016/j.imbio.2012.02.013
WOS ID WOS:000315312000005
Scopus ID 84871926460
Erfassungsdatum 2012-04-27
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