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Prudente de Mello, N. ; Berger, M. ; Lagerborg, K.A.* ; Yan, Y. ; Wettmarshausen, J. ; Keipert, S.* ; Weidner, L. ; Tokarz, J. ; Möller, G. ; Ciciliot, S.* ; Walia, S.R. ; Cheng, Y. ; Chudenkova, M. ; Artati, A. ; Weisenhorn, D.M. ; Wurst, W. ; Adamski, J. ; Nilsson, R.H.* ; Cossu, G.* ; Boon, A.J.W.* ; Kievit, A.J.A.* ; Mandemakers, W.* ; Bonifati, V.* ; Jain, M.* ; Jastroch, M.* ; Schmitt-Kopplin, P. ; Perocchi, F. ; Dyar, K.A.

Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease.

Mol. Metab. 97:102163 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Parkinson's disease (PD) is recognized as a systemic condition, with clinical features potentially modifiable by dietary intervention. Diets high in saturated fats and refined sugars significantly increase PD risk and exacerbate motor and non-motor symptoms, yet precise metabolic mechanisms are unclear. To investigate the interplay between diet and PD, we used a model of early-onset PD under chronic glycative stress induced by prolonged high-fat high-sucrose (HFHS) diet. We found this obesogenic diet drives loss of fat and muscle mass in early-onset PD mice, with a selective vulnerability of glycolytic myofibers. We show that PD mice and early-onset familial PD patients are under pervasive glycative stress with pathological accumulation of advanced glycation end products (AGEs), including two previously unknown glycerinyl-AGE markers.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Advanced Glycation Endproducts (ages) ; Biomarkers ; Glycative Stress ; Glycobiology ; Muscle Atrophy ; Parkinson's Disease; Dj-1; Age
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 2212-8778
e-ISSN 2212-8778
Zeitschrift Molecular Metabolism
Quellenangaben Band: 97, Heft: , Seiten: , Artikelnummer: 102163 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Obesity (IDO)
Research Unit BioGeoChemistry and Analytics (BGC)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
30505 - New Technologies for Biomedical Discoveries
30204 - Cell Programming and Repair
Forschungsfeld(er) Helmholtz Diabetes Center
Environmental Sciences
Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-502594-001
G-502295-001
G-504800-001
G-502200-001
A-630710-001
G-500500-001
G-500600-001
Förderungen Stichting Parkinson Fonds
Munich Graduate School of Systemic Neurosciences
Munich Center for Systems Neurology
Deutsches Zentrum fur Diabetesforschung
ExNet-0041-Phase2-3 through the Initiative and Network Fund of the Helmholtz Association (SyNergy-HMGU)
DOI 10.1016/j.molmet.2025.102163
WOS ID 001498383100001
Scopus ID 105005470061
PubMed ID 40345387
Erfassungsdatum 2025-05-11
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