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Auchynnikava, V. ; Semeia, L. ; Sippel, K. ; Sbierski-Kind, J. ; Fritsche, A. ; Birkenfeld, A.L. ; Paluscke-Fröhlich, J.* ; Wikström, A.K.* ; Preissl, H.

Fetal heart rate variability in relation to maternal physical activity and metabolic health.

Early Hum. Dev. 206:106272 (2025)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Physical activity (PA) during pregnancy may have a positive effect on the fetal cardiac maturation which is reflected in a decreasing resting heart rate and increasing heart rate variability (HRV). Different types of PA, for example during leisure or work time, have differential effects on HRV; however, this relationship has not yet been investigated in pregnancy. In our work, we related different types of PA during pregnancy with maternal and fetal HRV. We assessed the levels of PA in 95 pregnant women between 28 and 32 weeks of gestational age using the Baecke Physical Activity Questionnaire. Maternal and fetal heart rate and HRV were extracted from magnetocardiography recordings at rest, and maternal anthropometric and metabolic parameters were measured, such as fasting glucose and insulin levels, body mass index, and blood pressure. Pearson correlations were calculated between HRV, PA, and maternal parameters. Principal component analysis and generalized linear models were implemented to further investigate these relationships. Our findings indicate that habitual physical activity, whether during leisure or work, has no significant effect on maternal or fetal HRV at rest. However, leisure-time physical activity, unlike work-related activity, is associated with improved maternal insulin sensitivity. Additionally, our exploratory analyses revealed that lower HRV in both the mother and the fetus is associated with poorer maternal metabolic health quantified through higher fasting insulin levels, triglycerides, and adiposity. Finally, male fetuses showed higher HRV compared to females, highlighting the difference in cardiac development between the two biological sexes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Heart Rate Variability ; Insulin Sensitivity ; Physical Activity ; Pregnancy; Atherosclerosis Risk; Pregnancy; Exercise; Insulin; Glucose; Questionnaire
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 0378-3782
e-ISSN 1872-6232
Zeitschrift Early Human Development
Quellenangaben Band: 206, Heft: , Seiten: , Artikelnummer: 106272 Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen Add-on Fellowship of the Joachim Herz Foundation
International Max Planck Research School for the Mechanisms of Mental Function and Dysfunction (IMPRS-MMFD)
Federal Ministry of Education and Research (BMBF)
International Research Training Group: Women's Mental Health Across the Reproductive Years - German Research Foundation (DFG)
DOI 10.1016/j.earlhumdev.2025.106272
WOS ID 001510395000001
Scopus ID 105004391230
PubMed ID 40339304
Erfassungsdatum 2025-05-11
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