PuSH - Publikationsserver des Helmholtz Zentrums München: Interleukin 7 Signaling as an Indicator of Pulmonary Vascular Disease in Preterm Infants Identified by Proteomic Screening and MRI Analysis.

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Hilgendorff, A.* ; Kindt-Dunjko, A.* ; Häfner, F. ; Förster, K.* ; Heydarian, M. ; Hauck, S.M. ; Flemmer, A.W.* ; von Toerne, C. ; Sophia, S.* ; Toshner, M.* ; Sucre, J.M.S.*

Interleukin 7 Signaling as an Indicator of Pulmonary Vascular Disease in Preterm Infants Identified by Proteomic Screening and MRI Analysis.

Am. J. Respir. Crit. Care Med. 211, A7319 - A7319 (2025)

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Background: With an increasing percentage of extremely immature infants surviving, cardiopulmonary complications have become the most prevalent morbidity in this patient group. The underlying pathology of vascular disease (PVD) in preterms with chronic lung disease (BPD, bronchopulmonary dysplasia), associated with a high risk for progression into pulmonary hypertension (PH), is only incompletely understood and early, non-invasive biomarkers indicating early-stage disease are missing.Methods and Results: We prospectively included 190 preterm infants born <32 weeks postmenstrual age in the AIRR (Attention to Infants at Respiratory Risks) study (DRKS00004600) after informed parental consent. Identification of pathologic pulmonary artery flow and right heart strain by cardiopulmonary magnetic resonance imaging (MRI) at near-term age enabled us to identify plasma markers associated with PVD early after birth from proteomic screening. The differential regulation of IL-7 and its receptor IL7R, observed together with markers known from endothelial injury and remodeling , was confirmed by RNA scope analysis in human lung tissue (Vanderbilt University) from preterms with and without BPD and/or BPD-PH. Both vascular expression as well as cross talk to distinct immune cell populations was observed. Analysis of genetic data providing background information to this phenomenon is ongoing.Conclusion: Showcasing the regulation of IL-7R expression in infants with BPD indicates a role of IL7 signaling in PVD pathophysiology and outlines its potential as a disease marker and future therapeutic target.

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