PuSH - Publikationsserver des Helmholtz Zentrums München: ORF23 of murine gammaherpesvirus 68 is non-essential for <em>in vitro</em> and <em>in vivo</em> infection.

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Ohno, S. ; Steer, B. ; Sattler, C. ; Adler, H.

ORF23 of murine gammaherpesvirus 68 is non-essential for in vitro and in vivo infection.

J. Gen. Virol. 93, 1076-1080 (2012)

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Although ORF23 is conserved among gammaherpesviruses, its role during infection is unknown. Here, we studied the expression of ORF23 of murine gammaherpesvirus 68 (MHV-68) and its role during infection. ORF23 mRNA was detected in infected cells as a late transcript. The ORF23 protein product could be expressed and detected as an N-terminally FLAG-tagged protein by Western blot and indirect immunofluorescence. To investigate the role of ORF23 in the infection cycle of a gammaherpesvirus, we constructed an ORF23 deletion mutant of MHV-68. The analysis of the ORF23 deletion mutant suggested that ORF23 of MHV-68 is neither essential for replication in cell culture nor for lytic or latent infection in vivo. A phenotype of the ORF23 deletion mutant, reflected by a moderate reduction in lytic replication and latency amplification, was only detectable in the face of direct competition to the parental virus.

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