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Skerrett-Byrne, D.A. ; Pepin, A.-S. ; Laurent, K. ; Beckers, J. ; Schneider, R. ; Hrabě de Angelis, M. ; Teperino, R.

Dad's diet shapes the future: How paternal nutrition impacts placental development and childhood metabolic health.

Mol. Nutr. Food Res., DOI: 10.1002/mnfr.70261:e70261 (2025)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Early-life programming is a major determinant of lifelong metabolic health, yet current preventive strategies focus almost exclusively on maternal factors. Emerging experimental and preclinical data reveal that a father's diet before conception, particularly high-fat intake, also shapes offspring physiology. Here, we synthesize the latest evidence on how such diets remodel the sperm epigenome during two discrete windows of vulnerability: (i) testicular spermatogenesis, via DNA methylation and histone modifications, and (ii) post-testicular epididymal maturation, where small non-coding RNAs are selectively gained. We examine how these epigenetic signals influence pregnancy, placental development, and ultimately, metabolic trajectories in progeny. To extend published work, we sourced publicly available diet-induced sperm epigenome datasets and provide new potential connections of these changes to genes governing placental development, vascularization and size using the International Mouse Phenotyping Consortium data. Moreover, we further interrogate these overlaps with intricate in-silico analyses to examine their potential consequences. To foster meaningful interactions with these findings, we have developed a web application for ease (ShinySpermPlacenta). Collectively, these findings support a biparental model of preconception care and position the sperm epigenome as a promising tractable biomarker platform for personalized paternal nutrition counselling aimed at improving fertility and reducing intergenerational metabolic disease risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Shinyapp ; Epigenetics ; Inheritance ; Nutrient ; Paternal Preconception Health ; Placenta; Body-mass Index; High-fat Diet; Gene-expression; Insulin-resistance; Dna Methylation; Seminal Plasma; Fetal-growth; Mouse; Obesity; Fathers
Sprache englisch
Veröffentlichungsjahr 2025
HGF-Berichtsjahr 2025
ISSN (print) / ISBN 1613-4125
e-ISSN 1613-4133
Zeitschrift Molecular Nutrition and Food Research
Quellenangaben Band: , Heft: , Seiten: , Artikelnummer: e70261 Supplement: ,
Verlag Wiley
Verlagsort 111 River St, Hoboken 07030-5774, Nj Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Institute of Functional Epigenetics (IFE)
POF Topic(s) 30201 - Metabolic Health
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Genetics and Epidemiology
Helmholtz Diabetes Center
PSP-Element(e) G-500693-001
G-502800-001
G-500600-004
G-500600-001
Förderungen odowska-Curie postdoctoral fellowship
Marie Sklstrok
Helmholtz Gemeinschaft
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
German Center for Diabetes Research
National Health and Medical Research Council (NHMRC) Emerging Leadership Fellowship
DOI 10.1002/mnfr.70261
WOS ID 001564813900001
Scopus ID 105014957329
PubMed ID 40913545
Erfassungsdatum 2025-09-30
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