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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.
Gastroenterology 142, 1447-1450 (2012)
Studies of mechanisms responsible for the persistence of hepatitis B virus (HBV) infection have been hindered by a lack of appropriate animal models. HBV genomes can be delivered to livers of mice using hydrodynamic injection or high doses of an adenoviral vector; these lead to clearance of HBV. We found that infection of immunocompetent mice with low doses of an adenoviral vector resulted in persistent HBV infection; the mice neither underwent seroconversion to production of antibodies against HBV nor developed a strong HBV-specific effector T-cell response. As in patients with chronic HBV infection, DNA vaccination failed to generate T cells that cleared infection. This model of persistent HBV infection could be used to study the pathogenesis of chronic HBV infection and develop new therapeutic strategies.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
11.675
2.768
55
53
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Hepatitis-b-virus; Mouse Model; In-vivo; Interferon; Expression; Clearance; Responses; Cells; Liver; Dna; Mouse Model; Liver Disease; Virology; Immunity
Sprache
englisch
Veröffentlichungsjahr
2012
HGF-Berichtsjahr
2012
ISSN (print) / ISBN
0016-5085
e-ISSN
1528-0012
Zeitschrift
Gastroenterology
Quellenangaben
Band: 142,
Heft: 7,
Seiten: 1447-1450
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30203 - Molecular Targets and Therapies
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-551600-001
G-502700-003
G-502700-004
G-502700-003
G-502700-004
PubMed ID
22426294
WOS ID
WOS:000304778700022
Erfassungsdatum
2012-06-28