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Georgi, A.* ; Abou Jamra, R.* ; Klein, K.* ; Villela, A.W.* ; Schumacher, J.* ; Becker, T.* ; Paul, T.* ; Schmael, C.* ; Höfels, S. ; Klopp, N. ; Illig, T. ; Propping, P.* ; Cichon, S.* ; Nöthen, M.M.* ; Schulze, T.G.* ; Rietschel, M.*

Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample.

Psychiatr. Genet. 17, 308-310 (2007)

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Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite marker at GRIN1 in a German sample of 354 patients and 323 controls. We found significant associations in single-marker and haplotype-based analyses (P<0.05). Significance was more pronounced (P<0.01) in the subset of patients with a lifetime history of major depression, a subgroup of schizophrenia described previously as a promising phenotypic subtype in genetic studies of schizophrenia. Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia.

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