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Fernandez, I.E. ; Eickelberg, O.

The impact of TGF-β on lung fibrosis: From targeting to biomarkers.

Ann. Am. Thorac. Soc. 9, 111-116 (2012)
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Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis in different organs. Overproduction or potentiation of its profibrotic effects leads to an aberrant wound healing response during the initiation of fibrotic processes. Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating disease, in which TGF-βx{2013}induced disturbances of the homeostatic microenvironment are critical to promote cell activation, migration, invasion, or hyperplastic changes. In addition, excess extracellular matrix production contributes in a major way to disease pathogenesis. For this reason, this review will focus on discussing novel data and highlight growing interest in deepening the understanding of the profibrotic role of TGF-β and its direct or indirect targeting for disease modulation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 0
ISSN (print) / ISBN 2329-6933
e-ISSN 2325-6621
Zeitschrift Annals of the American Thoracic Society
Quellenangaben Band: 9, Heft: 3, Seiten: 111-116 Artikelnummer: , Supplement: ,
Verlag American Thoracic Society
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-001
PubMed ID 22802283
DOI 10.1513/pats.201203-023AW
Erfassungsdatum 2012-07-23
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