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Jochum, S. ; Ruiss, R.* ; Moosmann, A. ; Hammerschmidt, W. ; Zeidler, R.*

RNAs in Epstein-Barr virions control early steps of infection.

Proc. Natl. Acad. Sci. U.S.A. 109, E1396-E1404 (2012)
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Herpesviruses are dsDNA viruses, but their virions may additionally contain RNAs that can be transduced to recipient cells. The biological functions of herpes virion RNA species are unknown. Here we address this issue for EBV, a widespread human herpesvirus with oncogenic potential. We show that EBV-derived particles that include virions, virus-like particles, and subviral vesicles contain viral mRNAs, microRNAs, and other noncoding RNAs. Viral RNAs were transduced during infection and deployed immediate functions that enhanced EBV's capacity to transform primary B cells. Among these transduced viral RNAs, BZLF1 transcripts transactivated viral promoters triggering the prelatent phase of EBV infection, noncoding EBV-encoded RNA transcripts induced cellular cytokine synthesis, and BNLF2a mRNA led to immune evasion that prevented T-cell responses to newly infected B cells. Hence, transduced viral RNAs govern critical processes immediately after infection of B cells with EBV and likely play important roles in herpesviral infection in general.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter HUMAN B-CELLS; VIRUS-ENCODED INTERLEUKIN-10; TOLL-LIKE RECEPTOR; VIRAL INTERLEUKIN-10; EPITHELIAL-CELLS; GENE-EXPRESSION; IMMUNE EVASION; LYMPHOCYTE-B; TRANSFORMATION; DNA
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Zeitschrift Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Band: 109, Heft: 21, Seiten: E1396-E1404 Artikelnummer: , Supplement: ,
Verlag National Academy of Sciences
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Gene Vector (AGV)
CCG Immunooncology (AGV-KIO)
POF Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501500-001
G-521700-001
PubMed ID 22543160
DOI 10.1073/pnas.1115906109
WOS ID WOS:000304445800013
Scopus ID 84861428007
Erfassungsdatum 2012-07-23
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