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Wilde, S. ; Sommermeyer, D.* ; Frankenberger, B. ; Schiemann, M. ; Milosevic, S. ; Spranger, S. ; Pohla, H. ; Uckert, W.* ; Busch, D.H. ; Schendel, D.J.

Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity.

Blood 114, 2131-2139 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Adoptive transfer of T cells expressing transgenic T-cell receptors (TCRs) with antitumor function is a hopeful new therapy for patients with advanced tumors; however, there is a critical bottleneck in identifying high-affinity TCR specificities needed to treat different malignancies. We have developed a strategy using autologous dendritic cells cotransfected with RNA encoding an allogeneic major histocompatibility complex mole-cule and a tumor-associated antigen to obtain allo-restricted peptide-specific T cells having superior capacity to recognize tumor cells and higher functional avidity. This approach provides maximum flexibility because any major histocompatibility complex molecule and any tumor-associated antigen can be combined in the dendritic cells used for priming of autologous T cells. TCRs of allorestricted T cells, when expressed as transgenes in activated peripheral blood lymphocytes, transferred superior function compared with self-restricted TCR. This approach allows high-avidity T cells and TCR specific for tumor-associated self-peptides to be easily obtained for direct adoptive T-cell therapy or for isolation of therapeutic transgenic TCR sequences.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter melanoma-cells; cancer regression; gene-therapy; lymphocytes; receptor; expression; peptide; malignancies; recognition; generation
Sprache
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 2009
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 114, Heft: 10, Seiten: 2131-2139 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Verlagsort WASHINGTON
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
CCG Immune Monitoring (Platform) (IMI-KIM)
Institute of Virology (VIRO)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501700-001
G-520400-001
G-501700-005
G-501700-002
G-520100-001
DOI 10.1182/blood-2009-03-209387
Scopus ID 70349248241
PubMed ID 19587379
Erfassungsdatum 2009-12-31
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