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Lopez del Amo, J.M. ; Fink, U.* ; Dasari, M. ; Grelle, G.* ; Wanker, E.E.* ; Bieschke, J.* ; Reif, B.

Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.

J. Mol. Biol. 421, 517-524 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The green tea compound epigallocatechin-3-gallate (EGCG) inhibits Alzheimer's disease beta-amyloid peptide (A beta) neurotoxicity. Solution-state NMR allows probing initial EGCG-A beta interactions. We show that EGCG-induced A beta oligomers adopt a well-defined structure and are amenable for magic angle spinning solid-state NMR investigations. We find that EGCG interferes with the aromatic hydrophobic core of A beta. The C-terminal part of the A beta peptide (residues 22-39) adopts a beta-sheet conformation, whereas the N-terminus (residues 1-20) is unstructured. The characteristic salt bridge involving residues D23 and K28 is present in the structure of these oligomeric A beta aggregates as well. The structural analysis of small-molecule-induced amyloid aggregates will open new perspectives for Alzheimer's disease drug development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Alzheimer's Disease ; Beta-amyloid Peptide ; Magic Angle Spinning (mas) Solid-state Nmr Spectroscopy ; Drug Development ; Neurotoxicity; Solid-State Nmr; Amyloid Fibrils; Green Tea; Experimental Constraints; Peptide; Toxicity; Inhibitors; (-)-Epigallocatechin-3-Gallate; Neurotoxicity; Spectroscopy
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0022-2836
e-ISSN 1089-8638
Zeitschrift Journal of Molecular Biology
Quellenangaben Band: 421, Heft: 4-5, Seiten: 517-524 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)
POF Topic(s) 30203 - Molecular Targets and Therapies
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503090-001
G-503000-004
PubMed ID 22300765
DOI 10.1016/j.jmb.2012.01.013
WOS ID WOS:000308383800007
Scopus ID 84864281808
Erfassungsdatum 2012-09-27
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