PuSH - Publikationsserver des Helmholtz Zentrums München: Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA.

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Du, T.G.* ; Jellbauer, S.* ; Müller, M. ; Schmid, M.* ; Niessing, D. ; Jansen, R.P.*

Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA.

EMBO Rep. 9, 781-787 (2008)

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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

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Cytoplasmic localization and localized translation of messenger RNAs contribute to asymmetrical protein distribution. Recognition of localized mRNAs by RNA-binding proteins can occur in the cytoplasm or, alternatively, co- or post-transcriptionally in the nucleus. In budding yeast, mRNAs destined for localization are bound by the She2 protein before their nuclear export. Here, we show that a specific transcript, known as ASH1 mRNA, and She2 localize specifically to the nucleolus when their nuclear export is blocked. Nucleolar She2 localization is enhanced in a She2 mutant that cannot bind to RNA. A fusion protein of the amino terminus of She3 and She2 (She3N-She2) fails to enter the nucleus, but does not impair ASH1 mRNA localization. Instead, these cells fail to distribute Ash1 protein asymmetrically, which is caused by a defective translational control of ASH1 mRNA. Our results indicate that the nucleolar transit of RNA-binding proteins such as She2 is necessary for the correct assembly of translationally silenced localizing messenger ribonucleoproteins.

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