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Fluorescence Molecular Tomography using a-priori Photoacoustic data.
Proc. SPIE 6856:685617 (2008)
We present the first hybrid photoacoustic fluorescence molecular tomography system, capable of three-dimensional imaging of both fluorochrome and chromophore distributions in highly scattering and absorbing tissue. Quantitative three-dimensional maps of optical absorption coefficient are acquired using photoacoustic tomography. The reconstructed absorption data is fed into the Fluorescence Molecular Tomography inversion scheme in order to improve its accuracy and quatification capabilities in the presence of strong and distributed absorbers that are expected to bias stand-alone fluorescence reconstructions. At all, having both techniques in one hybrid modality yields a system that combines high molecular specificity and targeting flexibility of fluorescent imaging and high spatial resolution functional information obtained via photo-acoustic images.
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Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Herausgeber
Oraevsky, A.A.* ; Wang, L.V.*
Sprache
englisch
Veröffentlichungsjahr
2008
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Konferenztitel
Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acoust
Zeitschrift
Proceedings of SPIE
Quellenangaben
Band: 6856,
Artikelnummer: 685617
Reihe
Proceedings of SPIE
Verlag
SPIE
Verlagsort
Bellingham, WA
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-505500-001
Erfassungsdatum
2008-12-31