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    Minimizing activity and dose with enhanced image quality by radiopharmaceutical administrations.
        
        Radiat. Prot. Dosim. 139, 250-253 (2010)
    
    
    
				Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are administered to the patient, meaning not only a radiation exposure to the diseased tissue but also to the healthy tissues of large parts of the body. 'Minimizing Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations' (MADEIRA) is a project cofunded by the European Commission within the Seventh Euratom Framework Programme that aims to improve three-dimensional (3D) nuclear medical imaging technologies significantly. MADEIRA is aiming to improve the efficacy and safety of 3D PET and SPECT functional imaging by optimising the spatial resolution and the signal-to-noise ratio, improving the knowledge of the temporal variation of the radiopharmaceuticals' uptake in and clearance from tumourous and healthy tissues, and evaluation of the corresponding patient dose. Using an optimised imaging procedure that improves the information gained per unit administered dose, MADEIRA aims especially to reduce the dose to healthy tissues of the patient. In this paper, an overall summary of the current achievements will be presented.
			
			
		Impact Factor
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				0.707
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
     
    
    
        Schlagwörter
        Algorithms; Body Burden*; Computer Simulation; Dose-Response Relationship; Radiation; Humans; Image Enhancement/methods*; Image Interpretation; Computer-Assisted/methods; Models; Biological; Radiation Dosage*; Radiation Protection/methods; Radiometry/methods*; Radiopharmaceuticals/administration & dosage; Radiopharmaceuticals/analysis*; Radiopharmaceuticals/diagnostic use*; Reproducibility of Results; Sensitivity and Specificity; Tomography; Emission-Computed/methods*
    
 
     
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2010
    
 
     
    
        HGF-Berichtsjahr
        2010
    
 
    
    
        ISSN (print) / ISBN
        0144-8420
    
 
    
        e-ISSN
        1742-3406
    
 
     
     
     
	     
	 
	 
    
        Zeitschrift
        Radiation Protection Dosimetry
    
 
		
    
        Quellenangaben
        
	    Band: 139,  
	    Heft: 1-3,  
	    Seiten: 250-253 
	    
	    
	
    
 
  
         
        
            Verlag
            Oxford University Press
        
 
        
            Verlagsort
            Oxford
        
 
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Begutachtungsstatus
        Peer reviewed
    
 
     
    
        POF Topic(s)
        30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
    
 
    
        Forschungsfeld(er)
        Radiation Sciences
    
 
    
        PSP-Element(e)
        G-503600-002
G-503600-001
 
     
     	
    
    G-503600-001
        Scopus ID
        77953338210
    
    
        PubMed ID
        20228050
    
    
        Erfassungsdatum
        2010-07-28