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Hoeschen, C. ; Mattsson, S.* ; Cantone, M.C.* ; Mikuz, M.* ; Lacasta, C.* ; Ebel, G.* ; Clinthorne, N.* ; Giussani, A.

Minimizing activity and dose with enhanced image quality by radiopharmaceutical administrations.

Radiat. Prot. Dosim. 139, 250-253 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are administered to the patient, meaning not only a radiation exposure to the diseased tissue but also to the healthy tissues of large parts of the body. 'Minimizing Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations' (MADEIRA) is a project cofunded by the European Commission within the Seventh Euratom Framework Programme that aims to improve three-dimensional (3D) nuclear medical imaging technologies significantly. MADEIRA is aiming to improve the efficacy and safety of 3D PET and SPECT functional imaging by optimising the spatial resolution and the signal-to-noise ratio, improving the knowledge of the temporal variation of the radiopharmaceuticals' uptake in and clearance from tumourous and healthy tissues, and evaluation of the corresponding patient dose. Using an optimised imaging procedure that improves the information gained per unit administered dose, MADEIRA aims especially to reduce the dose to healthy tissues of the patient. In this paper, an overall summary of the current achievements will be presented.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Algorithms; Body Burden*; Computer Simulation; Dose-Response Relationship; Radiation; Humans; Image Enhancement/methods*; Image Interpretation; Computer-Assisted/methods; Models; Biological; Radiation Dosage*; Radiation Protection/methods; Radiometry/methods*; Radiopharmaceuticals/administration & dosage; Radiopharmaceuticals/analysis*; Radiopharmaceuticals/diagnostic use*; Reproducibility of Results; Sensitivity and Specificity; Tomography; Emission-Computed/methods*
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Quellenangaben Band: 139, Heft: 1-3, Seiten: 250-253 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-503600-002
G-503600-001
Scopus ID 77953338210
PubMed ID 20228050
Erfassungsdatum 2010-07-28