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Zeltser, L.M.* ; Seeley, R.J.* ; Tschöp, M.H.

Synaptic plasticity in neuronal circuits regulating energy balance.

Nat. Neurosci. 15, 1336-1342 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Maintaining energy balance is of paramount importance for metabolic health and survival. It is achieved through the coordinated regulation of neuronal circuits that control a wide range of physiological processes affecting energy intake and expenditure, such as feeding, metabolic rate, locomotor activity, arousal, growth and reproduction. Neuronal populations distributed throughout the CNS but highly enriched in the mediobasal hypothalamus, sense hormonal, nutrient and neuronal signals of systemic energy status and relay this information to secondary neurons that integrate the information and regulate distinct physiological parameters in a manner that promotes energy homeostasis. To achieve this, it is critical that neuronal circuits provide information about short-term changes in nutrient availability in the larger context of long-term energy status. For example, the same signals lead to different cellular and physiological responses if delivered under fasted versus fed conditions. Thus, there is a clear need to have mechanisms that rapidly and reversibly adjust responsiveness of hypothalamic circuits to acute changes in nutrient availability.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter HYPOTHALAMIC ARCUATE NUCLEUS; AGOUTI-RELATED PROTEIN; VENTRAL TEGMENTAL AREA; DIET-INDUCED OBESITY; PROOPIOMELANOCORTIN NEURONS; FEEDING CIRCUITS; NEUROPEPTIDE-Y; POMC NEURONS; INPUT ORGANIZATION; NPY/AGRP NEURONS
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Zeitschrift Nature Neuroscience
Quellenangaben Band: 15, Heft: 10, Seiten: 1336-1342 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)