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Emerging Risk Factors Collaboration (Döring, A. ; Meisinger, C.)

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: Individual participant meta-analysis.

Int. J. Epidemiol. 41, 1419-1433 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. METHODS: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. RESULTS: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. CONCLUSION: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Height; Height; cardiovascular disease; cancer; cause-specific mortality; epidemiological study; meta-analysis; cardiovascular disease; cancer; cause-specific mortality; epidemiological study; meta-analysis; CAUSE-SPECIFIC MORTALITY; CORONARY-HEART-DISEASE; CHILDHOOD SOCIOECONOMIC CIRCUMSTANCES; BODY-MASS INDEX; CANCER-RISK; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; MEN; WOMEN; ASSOCIATIONS
ISSN (print) / ISBN 0300-5771
e-ISSN 1464-3685
Zeitschrift International Journal of Epidemiology
Quellenangaben Band: 41, Heft: 5, Seiten: 1419-1433 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)