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Genomweite Assoziationsstudien (GWAS) - Möglichkeiten und Grenzen.
BioSpektrum 18, 508-510 (2012)
GWAS have brought many successes to detect DNA-variants for common diseases and other traits. Feasibility to genotype a large amount of SNPs cost efficiently in big populations with various study designs benefits GWAS in contrast to candidate gene studies. However, they only explain a small proportion of estimated heritability so far. It’s still a long way to go, to develop methods to discover false negative signals, find other impact e. g. from epigenetics or gene-environment interaction as well as to translate all findings into better understanding of disease and clinical practice.
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Anmerkungen
Besondere Publikation
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
deutsch
Veröffentlichungsjahr
2012
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0947-0867
e-ISSN
1868-6249
Zeitschrift
BioSpektrum
Quellenangaben
Band: 18,
Heft: 5,
Seiten: 508-510
Verlag
Springer
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Molecular Epidemiology (AME)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-504200-002
Scopus ID
84867457387
Erfassungsdatum
2012-12-12