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möglich sobald bei der ZB eingereicht worden ist.
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Nat. Struct. Mol. Biol. 20, 73-81 (2013)
The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the functional importance of this interaction remains elusive. Histone mRNAs are normally degraded at the end of S phase or after pharmacological inhibition of replication. Both processes are impaired in Eri1-deficient mouse cells, which instead accumulate oligouridylated histone mRNAs. Eri1 trims the mature histone mRNAs by two unpaired nucleotides at the 3' end but stalls close to the double-stranded stem. Upon oligouridylation of the histone mRNA, the Lsm1-7 heteroheptamer recognizes the oligo(U) tail and interacts with Eri1, whose catalytic activity is then able to degrade the stem-loop in a stepwise manner. These data demonstrate how degradation of histone mRNAs is initiated when 3' oligouridylation creates a cis element that enables Eri1 to process the double-stranded stem-loop structure.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
12.712
2.608
60
59
Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Binding-protein ; Translation Factors ; Dna-replication ; Microrna ; Yeast ; Degradation ; Uridylation ; Complex ; 3'-end ; 3'-exonuclease
Sprache
englisch
Veröffentlichungsjahr
2013
Prepublished im Jahr
2012
HGF-Berichtsjahr
2012
ISSN (print) / ISBN
1545-9993
e-ISSN
1545-9985
Zeitschrift
Nature Structural & Molecular Biology
Quellenangaben
Band: 20,
Heft: 1,
Seiten: 73-81
Verlag
Nature Publishing Group
Verlagsort
New York, NY
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Gene Vector (AGV)
Institute of Molecular Immunology (IMI)
Research Unit Molecular Immune Regulation (AMIR)
Institute of Molecular Immunology (IMI)
Research Unit Molecular Immune Regulation (AMIR)
POF Topic(s)
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-501500-004
G-501792-001
G-501793-001
G-501792-001
G-501793-001
PubMed ID
23202588
WOS ID
WOS:000313072400013
Scopus ID
84872026333
Erfassungsdatum
2012-12-31