PuSH - Publikationsserver des Helmholtz Zentrums München: Suppression of CD8<sup>+</sup> T cell recognition in the immediate-early phase of human cytomegalovirus infection.

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Hesse, J.* ; Ameres, S. ; Besold, K.* ; Krauter, S.* ; Moosmann, A. ; Plachter, B.*

Suppression of CD8⁺ T cell recognition in the immediate-early phase of human cytomegalovirus infection.

J. Gen. Virol. 94, 376-386 (2013)

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Human cytomegalovirus (HCMV) interferes with MHC class I-restricted antigen presentation and thereby reduces recognition by CD8+ T cells. This interference is primarily mediated by ER-resident glycoproteins that are encoded in the US2-11 region of the viral genome. Such a suppression of recognition would be of particular importance immediately after infection, because several immunodominant viral antigens are already present in the cell in this phase. However, it is not known which of the evasion proteins gpUS2-11 interfere with antigen presentation to CD8+ T cells at this time of infection. Here we address this question, using recombinant viruses (RV) that express only one of the immunoevasins gpUS2, gpUS3, or gpUS11. Infection with RV-US3 had only a limited impact on the presentation of peptides from the CD8+ T cell antigens IE1 and pp65 under immediate-early conditions imposed by cycloheximide-actinomycin D blocking. Unexpectedly, both RV-US2 and RV-US11 considerably impaired the recognition of IE1 and pp65 by CD8+ T cells, and both US2 and, to lesser extent, US11 were transcribed under IE conditions. Thus, gpUS2 and gpUS11 are key effectors of MHC class I immune evasion immediately after HCMV infection.

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PuSH - Publikationsserver des Helmholtz Zentrums München

Suppression of CD8+ T cell recognition in the immediate-early phase of human cytomegalovirus infection.

Suppression of CD8⁺ T cell recognition in the immediate-early phase of human cytomegalovirus infection.