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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Hourly variation in fine particle exposure is associated with transiently increased risk of ST segment depression.
Occup. Environ. Med. 65, 782-786 (2008)
Objectives: To evaluate whether hourly changes in fine particle (PM2.5, diameter, <2.5 mu m) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. Methods: 41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. The occurrence of ST segment depressions >0.1 mV was recorded during submaximal exercise tests. Hourly variations in personal PM2.5 exposure and outdoor levels of PM2.5 and ultrafine particles (<0.1 mu m) were recorded for 24 h before a clinic visit. Associations between particulate air pollution and ST segment depressions were evaluated using logistic regression. Results: Both personal and outdoor PM2.5 concentrations, but not outdoor ultrafine particle counts, were associated with ST segment depressions. The odds ratio (per 10 mu g/m(3)) for personal PM2.5 concentration during the hour preceding a clinic visit was 3.26 (95% CI 1.07 to 9.99) and for 4 h average outdoor PM2.5 it was 2.47 (95% CI 1.05 to 5.85). Conclusions: Even very short-term elevations in fine particle exposure might increase the risk of myocardial ischaemia. The precise mechanism is still unknown but could involve changes in autonomic nervous control of the heart.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
coronary-heart-disease; particulate air-pollution; elderly subjects; myocardial-infarction; rate-variability; ultrafine particles; inflammation; mortality; markers; matter
ISSN (print) / ISBN
1351-0711
e-ISSN
1470-7926
Zeitschrift
Occupational and Environmental Medicine
Quellenangaben
Band: 65,
Heft: 11,
Seiten: 782-786
Verlag
BMJ Publishing Group
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)