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Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
Bioessays 35, 242-252 (2013)
In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
5.423
1.180
32
32
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Fate Commitment ; Lineage ; Neural Stem Cell ; Neurogenesis; Neural Stem-cells ; Fibroblast Growth Factor-2 ; Nuclear Receptor Tlx ; Bone Morphogenetic Proteins ; In-vivo ; Subventricular Zone ; Self-renewal ; Hippocampal Neurogenesis ; Lineage Plasticity ; Progenitor Cells
Sprache
englisch
Veröffentlichungsjahr
2013
HGF-Berichtsjahr
2013
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Zeitschrift
BioEssays
Quellenangaben
Band: 35,
Heft: 3,
Seiten: 242-252
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-500800-001
PubMed ID
23335359
WOS ID
WOS:000314914400014
Scopus ID
84873569754
Erfassungsdatum
2013-03-15