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Ludwig, K.U.* ; Samann, P.* ; Alexander, M.* ; Beckers, J.* ; Bruder, J.* ; Moll, K.* ; Spieler, D. ; Czisch, M.* ; Warnke, A.* ; Docherty, S.J.* ; Davis, O.S.P.* ; Plomin, R.* ; Nöthen, M.M.* ; Landerl, K.* ; Müller-Myhsok, B.* ; Hoffmann, P.* ; Schumacher, J.* ; Schulte-Körne, G.* ; Czamara, D.*

A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.

Transl. Psychiatry 3:e229 (2013)
Verlagsversion Volltext DOI PMC
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The ability to perform mathematical tasks is required in everyday life. Although heritability estimates suggest a genetic contribution, no previous study has conclusively identified a genetic risk variant for mathematical performance. Research has shown that the prevalence of mathematical disabilities is increased in children with dyslexia. We therefore correlated genome-wide data of 200 German children with spelling disability, with available quantitative data on mathematic ability. Replication of the top findings in additional dyslexia samples revealed that rs133885 was a genome-wide significant marker for mathematical abilities(P-comb=7.71 x 10(-10), n=699), with an effect size of 4.87%. This association was also found in a sample from the general population (P=0.048, n=1080), albeit with a lower effect size. The identified variant encodes an amino-acid substitution in MYO18B, a protein with as yet unknown functions in the brain. As areas of the parietal cortex, in particular the intraparietal sulcus (IPS), are involved in numerical processing in humans, we investigated whether rs133885 was associated with IPS morphology using structural magnetic resonance imaging data from 79 neuropsychiatrically healthy adults. Carriers of the MYO18B risk-genotype displayed a significantly lower depth of the right IPS. This validates the identified association between rs133885 and mathematical disability at the level of a specific intermediate phenotype.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dyscalculia ; Dyslexia ; Genomic Imaging ; Mathematics ; Quantitative Trait ; Sulcal Morphology; Tumor-suppressor Gene ; Developmental Dyscalculia ; Association ; Cancer ; Brain ; Identification ; Prevalence ; Disability ; Disorders ; Correlate
Sprache englisch
Veröffentlichungsjahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 2158-3188
e-ISSN 2158-3188
Zeitschrift Translational Psychiatry
Quellenangaben Band: 3, Heft: , Seiten: , Artikelnummer: e229 Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500700-001
PubMed ID 23423138
DOI 10.1038/tp.2012.148
WOS ID WOS:000315993600004
Scopus ID 84874308194
Erfassungsdatum 2013-04-04
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