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Hultström, A.L.* ; Bratt, G.* ; Cosma, A. ; Erfle, V. ; Wahren, B.* ; Carbone, E.*

Autologous cytotoxicity of natural killer cells derived from HIV-infected patients.

Immunol. Lett. 91, 155-158 (2004)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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NK cells recognize target cells with reduced expression of MHC class I molecules. Human immunodeficiency virus (HIV) infection decreases MHC class I on the cell membrane. The aim of this study was to directly evaluate the role and conditions of NK cell effects in HIV seropositive patients ex vivo. Autologous HIV-infected CD4+ T cells were exposed to NK cells recognition. We discovered an increased lysis of the target cells after infection with human immunodeficiency virus-1 (HIV-1). The expression of the HIV-1 nef gene or the combined expression of nef and tat confers NK susceptibility to autologous CD4+ targets. Downregulation of MHC class I but not HLA-C or CD4 correlated with increased recognition by NK cells. The specific recognition is correlated with downregulation of MHC class I molecules on the infected target cells.

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