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Schulz, D.M. ; Böllner, C. ; Thomas, G.* ; Atkinson, M.J. ; Esposito, I. ; Höfler, H. ; Aubele, M.

Identification of differentially expressed proteins in triple-negative breast carcinomas using DIGE and mass spectrometry.

J. Proteome Res. 8, 3430-3438 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We compared the protein expression pattern of triple-negative breast carcinomas (HER2-, ER-, PR-) versus those being positive for HER2 and negative for the hormone receptors (HER2+, ER-, PR-) by 2-D DIGE and mass spectrometry. We obtained differential expression patterns for several glycolytic enzymes (as for example MDH2, PGK1, TKT, Aldolase1), cytokeratins (CK7, 8, 9, 14, 17, 19), further structure proteins (vimentin, fibronectin, L-plastin), for NME1-NME2, lactoferrin, and members of the Annexin family. Western blot analysis and immunohistochemistry were conducted to verify the results. The identified marker proteins may advance a more detailed characterization of triple-negative breast cancers and may contribute to the development of better treatment strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter proteomics; breast cancer; triple-negative; 2D-DIGE; MALDI-TOF/TOFMS; annexin a1 expression; nf-kappa-b; oxidative stress; epithelial-cells; messenger-rna; cancer cells; lactoferrin; tumors; progression; receptor
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 2009
ISSN (print) / ISBN 1535-3893
e-ISSN 1535-3907
Zeitschrift Journal of Proteome Research
Quellenangaben Band: 8, Heft: 7, Seiten: 3430-3438 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)
Institute of Radiation Biology (ISB)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
Forschungsfeld(er) Enabling and Novel Technologies
Radiation Sciences
PSP-Element(e) G-500300-001
G-500200-001
PubMed ID 19485423
DOI 10.1021/pr900071h
Scopus ID 67650388533
Erfassungsdatum 2009-09-03
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