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Progressive neurogenesis defines lateralis somatotopy.
Dev. Dyn. 239, 1919-1930 (2010)
Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2010
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1058-8388
e-ISSN
1097-0177
Zeitschrift
Developmental Dynamics
Quellenangaben
Band: 239,
Heft: 7,
Seiten: 1919-1930
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30204 - Cell Programming and Repair
Forschungsfeld(er)
Stem Cell and Neuroscience
PSP-Element(e)
G-500100-001
PubMed ID
20549716
Erfassungsdatum
2010-12-31