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Erfle, V. ; Schulte-Overberg, S. ; Marquart, K.H. ; Adler, I.-D. ; Luz, A.

Establishment and characterization of C-type RNA virus-producing cell lines from radiation-induced murine osteosarcomas.

J. Cancer Res. Clin. Oncol. 94, 149-162 (1979)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Eight cell lines were established from murine osteosarcomas induced in vivo with the radionuclides 224Ra and 227Th. They have been compared by light and electron microscopy, by karyology, and by their growth properties. The morphology, the growth pattern, and the ability to induce tumors in mice indicate that five of them are tumor cell lines. Chromosome studies demonstrated that the five cell lines have marker chromosomes. The other cell lines only showed some criteria generally used to score for transformation of fibroblasts and they may be derived from stromal cells. All cell lines release virus particles in the culture fluid which have the typical properties of RNA tumor viruses. They possess C-type morphology, a density of 1.16--1.18 g/cm3, a 60--70 S RNA, a RNA dependent DNA polymerase and they induce syncytia in rat XC cells. The possible significance of these virus particles in radiation osteosarcomagenesis is discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter C-type Rna Virus ; Cell Line ; Mice ; Radiation-induced Osteosarcoma
ISSN (print) / ISBN 0171-5216
e-ISSN 1432-1335
Zeitschrift Journal of Cancer Research and Clinical Oncology
Quellenangaben Band: 94, Heft: 2, Seiten: 149-162 Artikelnummer: , Supplement: ,
Verlag Springer
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed