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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
Hum. Mol. Genet. 22, 3597-3607 (2013)
Verlagsversion Volltext
DOI
PMC
Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6.24 × 10⁻⁹), GNPDA2 (P = 1.11 × 10⁻⁸) and POMC (P = 4.94 × 10⁻⁸) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10⁻⁵ after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages.
Impact Factor
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Web of Science
Times Cited
Times Cited
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7.692
1.762
51
87
Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2013
HGF-Berichtsjahr
2013
ISSN (print) / ISBN
0964-6906
e-ISSN
1460-2083
Zeitschrift
Human Molecular Genetics
Quellenangaben
Band: 22,
Heft: 17,
Seiten: 3597-3607
Verlag
Oxford University Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Genetic Epidemiology (IGE)
Institute of Experimental Genetics (IEG)
Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
Institute of Experimental Genetics (IEG)
Institute of Epidemiology (EPI)
Research Unit Molecular Epidemiology (AME)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30201 - Metabolic Health
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
30201 - Metabolic Health
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-504100-001
G-521500-002
G-503900-001
G-504200-001
G-504000-002
G-521500-002
G-503900-001
G-504200-001
G-504000-002
PubMed ID
23669352
Erfassungsdatum
2013-11-13