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McDonnell, L.A.* ; Walch, A.K. ; Stoeckli, M.* ; Corthals, G.L.*

MSiMass list: A public database of identifications for protein MALDI MSI.

J. Proteome Res. 13, 1138–1142 (2014)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The clinical application of mass spectrometry imaging has developed into a sizeable sub-discipline of proteomics and metabolomics because its seamless integration with pathology enables biomarkers and biomarker profiles to be determined that can aid patient and disease stratification (diagnosis, prognosis and response to therapy). Confident identification of the discriminating peaks remains a challenge owing to the presence of non-tryptic protein fragments, large mass-to-charge ratio ions that are not efficiently fragmented via tandem mass spectrometry or a high density of isobaric species. To aid the clinical development and implementation of mass spectrometry imaging a public database of identifications has been initiated. The MSiMass list database (www.maldi-msi.org/mass) enables users to assign identities to the peaks observed in their experiments and provides the methods by which the identifications were obtained. In contrast to existing protein databases, this list is designed as a community effort without a formal review panel. In this concept, authors can freely enter data, and can comment on existing entries. In such, the database itself is an experiment on sharing knowledge and its ability to rapidly provide quality data will be evaluated in the future.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Database ; Mass Spectrometry Imaging ; Msi ; Protein Identification; Mass-spectrometry; Tissue-sections; Gastric-cancer; Histology; Markers; Classification; Expression; Peptides; Fragment; Accurate
Sprache englisch
Veröffentlichungsjahr 2014
Prepublished im Jahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 1535-3893
e-ISSN 1535-3907
Zeitschrift Journal of Proteome Research
Quellenangaben Band: 13, Heft: 2, Seiten: 1138–1142 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Analytical Pathology (AAP)
Institute of Pathology (PATH)
POF Topic(s) 30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-500390-001
G-500300-001
PubMed ID 24313301
DOI 10.1021/pr400620y
WOS ID WOS:000331164100071
Scopus ID 84893856169
Erfassungsdatum 2013-12-11
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