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Takaku, Y.* ; Hwang, J.S.* ; Wolf, A. ; Böttger, A.* ; Shimizu, H.* ; David, C.N.* ; Gojobori, T.*

Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps.

Sci. Rep. 4:3573 (2014)
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Nerve cells and spontaneous coordinated behavior first appeared near the base of animal evolution in the common ancestor of cnidarians and bilaterians. Experiments on the cnidarian Hydra have demonstrated that nerve cells are essential for this behavior, although nerve cells in Hydra are organized in a diffuse network and do not form ganglia. Here we show that the gap junction protein innexin-2 is expressed in a small group of nerve cells in the lower body column of Hydra and that an anti-innexin-2 antibody binds to gap junctions in the same region. Treatment of live animals with innexin-2 antibody eliminates gap junction staining and reduces spontaneous body column contractions. We conclude that a small subset of nerve cells, connected by gap junctions and capable of synchronous firing, act as a pacemaker to coordinate the contraction of the body column in the absence of ganglia.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Electrical Synapses; Evolution; Genome; Organization; Proteins; System; Gene
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 4, Heft: , Seiten: , Artikelnummer: 3573 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOX)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-552500-001
PubMed ID 24394722
DOI 10.1038/srep03573
WOS ID WOS:000329359900001
Scopus ID 84891877472
Erfassungsdatum 2014-02-13
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