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MacIntyre, E.A. ; Gehring, U.* ; Mölter, A.* ; Fuertes, E. ; Klümper, C.* ; Krämer, U.* ; Quass, U.* ; Hoffmann, B.* ; Gascon, M.* ; Brunekreef, B.* ; Koppelman, G.H.* ; Beelen, R.* ; Hoek, G.* ; Birk, M. ; de Jongste, J.C.* ; Smit, H.A.* ; Cyrys, J. ; Gruzieva, O.* ; Korek, M.* ; Bergström, A.* ; Agius, R.M.* ; de Vocht, F.* ; Simpson, A.* ; Porta, D.* ; Forastiere, F.* ; Badaloni, C.* ; Cesaroni, G.* ; Esplugues, A.* ; Fernández-Somoano, A.* ; Lerxundi, A.* ; Sunyer, J.* ; Cirach, M.* ; Nieuwenhuijsen, M.J.* ; Pershagen, G.* ; Heinrich, J.

Air pollution and respiratory infections during early childhood: An analysis of 10 European birth cohorts within the ESCAPE project.

Environ. Health Perspect. 122, 107-113 (2014)
Verlagsversion Volltext DOI PMC
Open Access Gold
BACKGROUND: Few studies have investigated traffic-related air pollution as a risk factor for respiratory infections during early childhood. OBJECTIVES: We aimed to investigate the association between air pollution and pneumonia, croup, and otitis media in 10 European birth cohorts--BAMSE (Sweden), GASPII (Italy), GINIplus and LISAplus (Germany), MAAS (United Kingdom), PIAMA (the Netherlands), and four INMA cohorts (Spain)--and to derive combined effect estimates using meta-analysis. METHODS: Parent report of physician-diagnosed pneumonia, otitis media, and croup during early childhood were assessed in relation to annual average pollutant levels [nitrogen dioxide (NO2), nitrogen oxide (NOx), particulate matter≤2.5 μm (PM2.5), PM2.5 absorbance, PM10, PM2.5-10 (coarse PM)], which were estimated using land use regression models and assigned to children based on their residential address at birth. Identical protocols were used to develop regression models for each study area as part of the ESCAPE project. Logistic regression was used to calculate adjusted effect estimates for each study, and random-effects meta-analysis was used to calculate combined estimates. RESULTS: For pneumonia, combined adjusted odds ratios (ORs) were elevated and statistically significant for all pollutants except PM2.5 (e.g., OR=1.30; 95% CI: 1.02, 1.65 per 10-μg/m3 increase in NO2 and OR=1.76; 95% CI: 1.00, 3.09 per 10-μg/m3 PM10). For otitis media and croup, results were generally null across all analyses except for NO2 and otitis media (OR=1.09; 95% CI: 1.02, 1.16 per 10-μg/m3). CONCLUSION: Our meta-analysis of 10 European birth cohorts within the ESCAPE project found consistent evidence for an association between air pollution and pneumonia in early childhood, and some evidence for an association with otitis media.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Use Regression-models; 1st 2 Years; Particulate Matter; Otitis-media; Pm2.5 Absorbency; Children Younger; Exposure; Life; Outdoor; Health
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Zeitschrift Environmental Health Perspectives
Quellenangaben Band: 122, Heft: 1, Seiten: 107-113 Artikelnummer: , Supplement: ,
Verlag Research Triangle Park
Verlagsort NC [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-504000-004
PubMed ID 24149084
DOI 10.1289/ehp.1306755
WOS ID WOS:000332644200027
Scopus ID 84891503527
Erfassungsdatum 2014-03-05
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