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Hagopian, W.A.* ; Lernmark, A.* ; Rewers, M.J.* ; Simell, O.G.* ; She, J.X.* ; Ziegler, A.-G.* ; Krischer, J.P.* ; Akolkar, B.*

TEDDY--The Environmental Determinants of Diabetes in the Young: An observational clinical trial.

Ann. NY Acad. Sci. 1079, 320-326 (2006)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

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